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Available options include: B12 Shots : Intramuscular injections (IM) are the most commonly used treatment because they bypass absorption barriers and deliver the vitamin directly into the bloodstream[21]

This is done first by obtaining cystathionine (an intermediate of cysteine) through CBS (cystathionine beta synthase), which uses the pyridoxal factor of vitamin B6 as a cofactor, forming cystathionine, from homocysteine and serine (an amino acid involved in purine synthesis and a precursor of glycine)

Supplementary Table S2)

10.1074/jbc.M404751200 280 YangY.LiuJ.-p.FangJ.-y.WangH.-c.WeiY.CaoY.et al (2019)

It has been extensively studied in animal models for its regenerative effects across multiple tissue types, including tendon, ligament, vascular endothelium, muscle, and intestinal mucosa